Pain is a highly unpleasant sensation caused by illness or injury. Sciatica is a medical condition refers to intense pain emerging from deep nerve root that further radiates up to leg. Non-steroidal anti-inflammatory drugs (NSAIDs) have been used to manage musculoskeletal symptoms since antiquity. But the major crisis of using NSAIDs for long term results in stomach ulcer, hypertension, liver and kidney dysfunction. Herbs are considered to be safe alternative therapy for clinical management of sciatica as it has no side effects and provides convincing relief in patients. The plant Nyctanthes arbor-tristis commonly called as Pavalamalli in Tamil is known for its traditional analgesic and anti-inflammatory property for years together. Still now there is no proper clinical validation were done in subjects with clinical condition called Sciatica. Hence present investigation was adopted to establish the clinical therapeutic efficacy of the leaf decoction of N. arbor-tristis on subjects with varying degree of sciatica. A total of 10 patients of which 5 males and 5 females with persistent sciatica from 6 months to 3 years duration were included into the study and the subjects were treated with leaf decoction of N. arbor-tristis for the period of 30 days. The result of present clinical investigation has revealed that the leaf decoction of N. arbor-tristis has shown good improvement in 6 patients (60%), moderate improvement in 2 patients (20%), mild improvement in 1 patient (10%) and no improvement observed in 1 patient. Hence from the study it was concluded that the trial drug are therapeutically effective in clinical management of sciatica (Vathasthambam).