Related substances of azilsartan medoxomil: Synthesis and characterization | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Related substances of azilsartan medoxomil: Synthesis and characterization

Author(s): Madhuresh K. Sethi, Vijendra Singh Rawat, Jayaprakash Thirunavukarasu, Raja Krishna Yeramalla and Anish Kumar

AzilsartanMedoxomil is the prodrug 2-ethoxy-1-([2'-(5- oxo 4, 5 – dihydro - 1, 2, 4-oxadiazol-3-yl) biphenyl-4- yl]methyl) 1H-benimidazole-7-carboxylic acid which is used as a antihypertensive drug. During the process optimization of Azilsartanmedoxomil novel related substances (impurities) were observed. These related substances were prepared and characterized by MASS, NMR and HPLC.


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