Hypertension is the most prevalent cardiovascular disease in the developed as well as developing countries, affecting about 20 – 30% of the adult population. It is an independent risk factor for cardiovascular disease and is associated with an increased incidence of stroke and coronary heart disease. To control the risk factors several types of antihypertensive drugs are used in the world. Therefore, pharmacodynamic and pharmacokinetic studies are utmost important for the quality control. The advent of electronics has allowed to develop more sensitive, reliable and less expensive instrumentations which have significant contribution in the field of drug development and analysis. The use of various types of modified electrodes in the voltammetrictechniques and spectrophotometric method play an important role due to its advantages over other sophisticated instruments in terms of low cost, simplicity and portability.