Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


SbCl3-HAP catalyzed aza-Michael addition of aliphatic amines to α,β -unsaturated carbonyl compounds and nitriles

Author(s): Rajni Khajuria, Raj Kumar, Deepali Mahajan,* and Kamal K. Kapoor

An efficient aza-Michael addition of aliphatic amines (primary and secondary) to a series of α,β-unsaturated carbonyl compounds and nitriles has been carried out using antimony (III) chloride supported over hydroxyapetite (SbCl3-HAP) as an effective catalyst in acetonitrile to produce the corresponding β-amino derivatives in high yields. The method is simple, general and offers limited chemoselectivity, as aromatic amines were found to be unreactive.