Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
SbCl3-HAP catalyzed aza-Michael addition of aliphatic amines to �±,�² -unsaturated carbonyl compounds and nitriles
Author(s): Rajni Khajuria, Raj Kumar, Deepali Mahajan,* and Kamal K. KapoorAn efficient aza-Michael addition of aliphatic amines (primary and secondary) to a series of α,β-unsaturated carbonyl compounds and nitriles has been carried out using antimony (III) chloride supported over hydroxyapetite (SbCl3-HAP) as an effective catalyst in acetonitrile to produce the corresponding β-amino derivatives in high yields. The method is simple, general and offers limited chemoselectivity, as aromatic amines were found to be unreactive.
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Citations : 25868
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