Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Schiff base synthesis by unconventional route: An innovative green approach

Author(s): Atul R. Bendale, Rohit Bhatt, Akhil Nagar, Anil Jadhav and G Vidyasagar

The objective of present research work is to provide green methodologies for synthesis of Schiff bases. Highly efficient and simple methods have been described for the synthesis with excellent yields (95-98%). Synthesis of Schiff base is often carried out with or without acidcatalysed and generally by refluxing the mixture of aldehyde (or ketone) and amine in organic medium. Present synthesis complies with principle of Green chemistry. As part of current studies, we here in reports efficient practical techniques like- sonication (sonochemistry), UV radiations and simple mortal-pastel method (mechanochemistry). The overall progress of the reaction was monitored by TLC and characterized by IR and NMR. Compared with traditional methods, these methods are more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. Low cost, simple to run, maximum efficiency are some advantages of these techniques. Compared with traditional methods, these methods are more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. From these features present methods can be correlated for safer and efficient synthesis of other products.


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