Selective phosphoinositide 3-kinase inhibition by natural products: A molecular docking study | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey


Selective phosphoinositide 3-kinase inhibition by natural products: A molecular docking study

Author(s): David A. Jackson and William N. Setzer*

Phosphoinositide 3-kinase (PI3K) is responsible for a large number of signaling pathways involved in a range of conditions ranging from allergic response to tumor growth, and much research is currently underway to identify novel selective inhibitors for the different isoforms of PI3K. In this work, a molecular docking analysis of 80 antiinflammatory natural products was carried out with three isoforms of PI3K in order to identify potential selective inhibitors from natural sources. Seven natural products with “drug-like” properties were found to dock strongly and selectively with PI3K. These include the alkaloids berberine, chelerythrine, and isaindigotone; the flavonoids malvidin, isovitexin, and vitexin; and the triterpenoid cucurbitacin B.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Recommended Conferences
Google Scholar citation report
Citations : 11575

Der Pharma Chemica received 11575 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons

rokettube brazzers

Turkish dental care is known to be affordable compared to other countries. If you want an affordible dentist Turkey, check out periodonta. It is heavily recommended for dental patients visiting Turkey