Background: Erectile Dysfunction (ED) is a distressing problem in Chronic Renal Failure (CRF) and Hemodialysis (HD) patients and could be attributed to anemia which worsens the general condition and aggravates asthenia. Aim of the works: Detection of the prevalence of Erectile Dysfunction (ED) in Chronic Renal Patients (CRF) on Hemodialysis (HD). Patients and methods: 50 patients on HD were assessed using IIEF-5 score, hormonal assay for Luteinizing Hormone (LH), prolactin and testosterone (total and free) and penile duplex study. Results: ED has very wide prevalence in CRF patients on HD with variable changes in levels of hormones and in duplex results. Conclusion: Prevalence of ED in CRF patients on HD is about 100% with variable degrees from mild to severe with changes in associated hormonal levels and results of duplex study.