Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Significance of Redox Studies on Branched Polysaccharides during Metal Complex Formation

Author(s): Madhuresh K Sethi, Anish Kumar, Rohit Shukla, Jayaprakash Thirunavukarasu, Jaganmohanarao Bontalakoti, Lakshminarayana Vemula, Rajakrishna Yerramalla, Sanjay Mahajan, Purbita Chakraborty

Detailed studies on oxidation and reduction of complex polysaccharides were studied. Low molecular weight glucan like dextran has been oxidized using different quantities of sodium hypochlorite and the number of glucose units oxidized has been analyzed using potentiometric titrations. Different factors such as the quantity of sodium hypochlorite, reaction duration, isolation have been comprehensively studied. The oxidized product has been analyzed by Proton Nuclear Magnetic Resonance (1HNMR), Carbon-13 nuclear magnetic resonance (13C NMR), Infra-Red (IR) and Gel Permeation Chromatography (GPC). Similarly low molecular weight dextran has been hydrogenated using different quantities sodium borohydride and percentage reduction was calculated using reducing sugar content.


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