Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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Simple route for the synthesis of pyrido [1, 2-a] pyrimidine derivatives

Author(s): Raghunath B. Toche*a, Pankaj B. Awarea, Satish M. Chavanb, Vasant M. Patila and Poonam S. Patila

Facile synthesis of p-substituted benzoyl-3-(2-amino-N-hetero-2-alkenenitrile 4 was obtained by one pot three component reaction of aroylacetonitrile 1, 2-amino-N-hetero compound 2 and orthoestes 3, at 80°C with 65-70% yield. The alkylnitrile 4 was cyclized to pyrido[1,2-a] pyrimidine derivatives 5 in presence of Conc. hydrochloric acid with 60 -89% yields.


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