Facile synthesis of p-substituted benzoyl-3-(2-amino-N-hetero-2-alkenenitrile 4 was obtained by one pot three component reaction of aroylacetonitrile 1, 2-amino-N-hetero compound 2 and orthoestes 3, at 80°C with 65-70% yield. The alkylnitrile 4 was cyclized to pyrido[1,2-a] pyrimidine derivatives 5 in presence of Conc. hydrochloric acid with 60 -89% yields.
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