All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.
Simple route for the synthesis of pyrido [1, 2-a] pyrimidine derivatives
Author(s): Raghunath B. Toche*a, Pankaj B. Awarea, Satish M. Chavanb, Vasant M. Patila and Poonam S. Patila
Facile synthesis of p-substituted benzoyl-3-(2-amino-N-hetero-2-alkenenitrile 4 was obtained by one pot three component reaction of aroylacetonitrile 1, 2-amino-N-hetero compound 2 and orthoestes 3, at 80°C with 65-70% yield. The alkylnitrile 4 was cyclized to pyrido[1,2-a] pyrimidine derivatives 5 in presence of Conc. hydrochloric acid with 60 -89% yields.