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Simple validated isocratic RP-HPLC method for estimation of Tolperisone in bulk and pharmaceutical dosage form | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Simple validated isocratic RP-HPLC method for estimation of Tolperisone in bulk and pharmaceutical dosage form

Author(s): Murali. M and Satyanarayana. P. V. V

A simple, rapid reverse phase high performance liquid chromatographic method has been developed and validated for estimation of Tolperisone in pharmaceutical dosage form. The estimation was carried out on Inertsil ODS C-18, 5μm column having 250 x 4.6mm internal diameter column with a mixture of methanol: acetonitrile in the ratio of 90:10:(v/v) as mobile phase. UV detection was performed at 232 nm. The method was validated for linearity, accuracy, precision and specificity as per ICH norms. The developed and validated method was successfully used for the quantitative analysis of commercially available dosage form. The retention time was 2.48 min. for Tolperisone and total run time was 5 min. at a flow rate of 1.0 ml/min. The calibration curve was linear over the concentration range of 40-100 ppm for Tolperisone. The LOD and LOQ values were found to be 0.5 and 3 ppm respectively. The high percentage of recovery confirms the suitability of the method for the estimation of Tolperisone in pharmaceutical dosage form.


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