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Simultaneous analysis of Paracetamol and Tramadol - Analytical method development and validation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Simultaneous analysis of Paracetamol and Tramadol - Analytical method development & validation

Author(s): Sridhar Narayan, Pradeep Kumar, Rakesh K Sindhu, Ayushman Tiwari, Manik Ghosh

In the present study the development and validation of analytical method was carried out for simultaneous analysis of paracetamol and tramadol using first derivative method. The λ max was determined for paracetamol and tramadol and standard curves were plotted. The stability of the stock solutions with due course of time was also determined and compared using t-Test. Further the simultaneous analysis at 1:1, 8:1 and 1:8 ratios revealed the need of a higher derivative method for the simultaneous estimation of paracetamol and tramadol in various dosage forms.


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