Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Simultaneous derivative and multicomponent spectrophotometric determination of Simvastatin and Ezetimibe in tablets

Author(s): Joshi H. V, J. K. Patel, Lata Kothapalli

Two new, simple, accurate and economical spectrophotometric methods have been developed for simultaneous estimation of simvastatin and ezetimibe in two component tablet formulation. The methods employed are first order derivative spectrophotometry using zero crossing techniques and multicomponent analysis both the drugs obey the Beer’s law in the concentration range employed for these methods. The results of analysis are validated statistical evaluation and recovery studies.


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