GET THE APP

Simultaneous Determination of Paracetamol, Lornoxicam and Chlorzoxazone in Tablets by High Performance Thin Layer Chromatography | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Simultaneous Determination of Paracetamol, Lornoxicam and Chlorzoxazone in Tablets by High Performance Thin Layer Chromatography

Author(s): Savita S Yadav, Anuradha S Jagtap, Janhavi R Rao

A simple, specific, accurate and precise HPTLC method for simultaneous estimation of paracetamol, lornoxicam and chlorzoxazone as the bulk drug and in tablet dosage form. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of chloroform: toluene: methanol: glacial acetic acid 6: 3: 1: 0.04 (v/v/v/v). Densitometric evaluation of the separated zones was performed at 275 nm. The three drugs were satisfactorily resolved with RF values 0.26 ± 0.02, 0.45 ± 0.03 and 0.53 ± 0.01 for paracetamol, lornoxicam and chlorzoxazone respectively. The method can be used for estimation of combination of these drugs in tablets. The method was validated as per ICH guidelines. The linearity of developed method was achieved in the range of 10 – 50 ng/spot for each of paracetamol, lornoxicam and chlorzoxazone and recoveries from tablets were between 99.27 ± 0.70, 99.37 ± 0.06 and 99.10 ± 0.30 %. Due to these attributes, the proposed method could be used for routine quality control analysis of these drugs in combined dosage forms.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Recommended Conferences

19th European Organic Chemistry Congress
London, UK
Google Scholar citation report
Citations : 11575

Der Pharma Chemica received 11575 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry