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Simultaneous estimation and forced degradation studies of amlodipine besylate and indapamide in tablet dosage form by RP-HPLC method | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Simultaneous estimation and forced degradation studies of amlodipine besylate and indapamide in tablet dosage form by RP-HPLC method

Author(s): Rashmita G, Vasanth P. M*, Ramesh T and Ramesh M

The method developed for simultaneous estimation of Amlodipine besylate and Indapamide by using RP-HPLC method is simple, accurate, selective and economic by using c8 column (BDS Hypersil, 100×4.6mm,5μ particle size). Sample was analysed using water which is adjusted with ortho phosphoric acid buffer (OPA) to pH 3: Methanol in the ratio 600:400 as a mobile phase at a flow rate of 1ml\min. Detection was performed with PDA detector at 248nm. The retention time of Indapamide and Amlodipine besylate is 1.45 & 3.30 respectively. The correlation coefficient R2 value is found to be 0.999 for Amlodipine besylate and 0.999 for Indapamide. The LOD and LOQ values for Amlodipine besylate was found to be 0.00015 and 0.0005.The LOD and LOQ values for Indapamide was found to be 0.00028 and 0.00095 respectively. The proposed method was validated as per ICH guidelines with parameters like linearity, accuracy, Interday and precision, LOD, LOQ, robustness.


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