Simultaneous estimation of lansoprazole and naproxen by using UV spectrophotometer in tablet dosage form | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


Simultaneous estimation of lansoprazole and naproxen by using UV spectrophotometer in tablet dosage form

Author(s): Nisha Choudhary, Inamullah Siddiqui, Jyoti Rai, Sunil Singh, Sharma Surabhi and Hemendar Gautam

An accurate, specific and precise UV spectrophotometric method was developed for the simultaneous determination of lansoprazole and naproxen. The indicating proposed method was accurate and precise for simultaneous estimation of NAP and LAN in tablet dosage form by using Simultaneous Equation. Materials used were UV- - Visible Spectrometer (LAB INDIA 3200) with 1cm quartz cells. An analytical balance (Roy electronics – LCBCNS) was used for weighing the samples. Means, standard deviation (SD), relative standard deviation (RSD) and linear regression analysis were calculated using Microsoft Excel 2007. The maximum wavelength (λmax) was found to be 284 nm for LAN and 271 nm for NAP. The linearity was found to be 10-35μg/ml (r2 =0·999) for NAP and 5-30μg/ml (r2=0·998) for LAN. Validation was performed as ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The limit of quantification of NAP was found to be 0·15μg/ml and for LAN was 1·7μg/ml. The limit of detection of NAP was found to be 0·04μg/ml and for LAN was 0·5μg/ml. The % recovery was found to be satisfactory. The proposed method is simple, sensitive and reproducible for simultaneous determination of UV Spectrophotometric method for lansoprazole and Naproxen in tablet dosage form.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry