Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Simultaneous estimation of lansoprazole and naproxen by using UV spectrophotometer in tablet dosage form

Author(s): Nisha Choudhary, Inamullah Siddiqui, Jyoti Rai, Sunil Singh, Sharma Surabhi and Hemendar Gautam

An accurate, specific and precise UV spectrophotometric method was developed for the simultaneous determination of lansoprazole and naproxen. The indicating proposed method was accurate and precise for simultaneous estimation of NAP and LAN in tablet dosage form by using Simultaneous Equation. Materials used were UV- - Visible Spectrometer (LAB INDIA 3200) with 1cm quartz cells. An analytical balance (Roy electronics – LCBCNS) was used for weighing the samples. Means, standard deviation (SD), relative standard deviation (RSD) and linear regression analysis were calculated using Microsoft Excel 2007. The maximum wavelength (λmax) was found to be 284 nm for LAN and 271 nm for NAP. The linearity was found to be 10-35μg/ml (r2 =0·999) for NAP and 5-30μg/ml (r2=0·998) for LAN. Validation was performed as ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The limit of quantification of NAP was found to be 0·15μg/ml and for LAN was 1·7μg/ml. The limit of detection of NAP was found to be 0·04μg/ml and for LAN was 0·5μg/ml. The % recovery was found to be satisfactory. The proposed method is simple, sensitive and reproducible for simultaneous determination of UV Spectrophotometric method for lansoprazole and Naproxen in tablet dosage form.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş