Three new spectrophotometric procedures for the simultaneous determination of Mefenamic acid and Drotaverine HCL are described. The chromatography was performed on an ODS-3V, 250 X 4.6 mm, 5μ. Column at 250C, with a mobile phase Phosphate buffer: Acetonitrile (45:55v/v). The flow rate was 1.5ml/min and UV detection wavelength was 350nm. This method permitsthe simultaneous determination of Mefenamic Acid and Drotaverine HCL in fermentative foods with detection limits of 5.625 and 0.033 lg/mL, respectively. The corelation coefficient was found to be 0.998 and 0.999 for Mefenamic acid and Drotaverine HCL respectively. Drug assay was performed in triplicate as a test of accuracy. The average percentage recovery of Mefenamic acid and Drotaverine HCL was found to be 101.2% and 101.1% .The proposed method could be used to be simple, accurate, precise, and rapid and could be used for routine analysis. This condition is applied for tablet dosage form. The statistical parameters and recovery studies were carried out and reported.