Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Simultaneous Estimation of Mefenamic Acid and Drotaverine HCL in Combined Dosage Form by RP-HPLC Method and Validation of the Developed method

Author(s): D. C. Permanand, K. L. Senthilkumar, B. Senthilkumar, M.Saravanakumar and R.Thirumurthy

Three new spectrophotometric procedures for the simultaneous determination of Mefenamic acid and Drotaverine HCL are described. The chromatography was performed on an ODS-3V, 250 X 4.6 mm, 5μ. Column at 250C, with a mobile phase Phosphate buffer: Acetonitrile (45:55v/v). The flow rate was 1.5ml/min and UV detection wavelength was 350nm. This method permitsthe simultaneous determination of Mefenamic Acid and Drotaverine HCL in fermentative foods with detection limits of 5.625 and 0.033 lg/mL, respectively. The corelation coefficient was found to be 0.998 and 0.999 for Mefenamic acid and Drotaverine HCL respectively. Drug assay was performed in triplicate as a test of accuracy. The average percentage recovery of Mefenamic acid and Drotaverine HCL was found to be 101.2% and 101.1% .The proposed method could be used to be simple, accurate, precise, and rapid and could be used for routine analysis. This condition is applied for tablet dosage form. The statistical parameters and recovery studies were carried out and reported.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan