A fast, simple, precise, accurate and robust HPTLC method was developed for simultaneous determination of paracetamol and dexketoprofen trometamol in tablet dosage form. Silica gel G 60F254 plates were used as stationary phase and toluene: ethyl acetate: acetic acid (6: 4: 0.2 v/v/v) as mobile phase. Wavelength selected for analysis was 256 nm. The two drugs were satisfactorily resolved with Rf 0.20 ± 0.02 and 0.55 ± 0.02 for paracetamol and dexketoprofen trometamol respectively. Linearity was found to be in the range of 25-150 ng/spot for paracetamol, 100-600 ng/spot for dexketoprofen trometamol. Intra-day and inter-day precision were found to be (%RSD) 0.94–1.58 % and 1.14–1.83 % for paracetamol and (%RSD) 0.67–1.03 % and 0.49–1.18 for dexketoprofen trometamol. Accuracy of paracetamol and dexketoprofen trometamol was found to be 99.91 % and 99.56 %, respectively. The proposed method can be used for routine simultaneous analysis of paracetamol and dexketoprofen trometamol.
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