Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Simultaneous spectrophotometric estimation of Paracetamol and Dexketoprofen Trometamol in pharmaceutical dosage form

Author(s): Lata P. Kothapalli, Archana K. Karape, Asha B. Thomas, Rabindra K. Nanda, Poonam Gaidhani and Madhuri E. Choudhari

NSAIDs are often used for their anti-inflammatory, analgesic, and/or antipyretic effects. The aim of combining two analgesic agents is to get synergistic analgesic effects of the individual drugs. Two simple spectrophotometric methods have been developed for simultaneous estimation of Paracetamol and Dexketoprofen Trometamol from pharmaceutical dosage form. Method-I involved simultaneous equation method and Method-II is the Q-absorbance method. For simultaneous equation method the absorbances of the standard solutions were taken at two wavelengths 243.0 nm (working wavelength of paracetamol) instead of 248 .0 nm (lmax of paracetamol) and 253.0 nm (lmax of dexketoprofen trometamol). For Qabsorbance method the absorbances of the standard solutions were taken at two wavelengths 248.0 nm (lmax of paracetamol) and 266.0 nm (Isobestic point), in methanol and linearity range selected was 8-28 mg/ml for paracetamol and 0.4-1.4 mg/ml for dexketoprofen trometamol for both methods based on the ratio of the two drugs in combined dosage form. The accuracy and precision of the methods were determined and validated statistically. All the methods showed good reproducibility and recovery with RSD less than 2. The methods were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of paracetamol and dexketoprofen trometamol in bulk and in pharmaceutical dosage form.


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