Solanum nigrum or locally just black nightshade is a species in the Solanum genus, native to Eurasia and introduced in the Americas, Australasia, and South Africa. While this plant has lots of properties, the aim of this study is to overview its therapeutic effects of Solanum nigrum. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases from 1998 to 2016.totally, of 93 found articles, 60 articles were included. The search terms were “Solanum nigrum”, “therapeutic”, “pharmacological”, Various studies have shown that Solanum nigrum Possess Anti-Tumor effect, Anti-Cancer Activity, Hepatoprotective Effect, Anti-fungal effect, Anti -larvicidal effect, Anti-Stress effect, Antioxidative effect, Antiallergic effect, Estrogenic activity. Although Solanum nigrum have a long history of medicinal use within the traditional Chinese system, it has been only recently in the West that we have begun to understand their pharmacological possibilities. Solanum nigrum has a wide range of potential therapeutic applications in anti-cancer and anti-tumor activities.