Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Solvent-free, instant, ambient, n-boc protection of amines -A green, recyclable heterogenous acid catalysis by Amberlite-IR 120

Author(s): Vijay Kumar Pasala

A facile and versatile method for the N-tert-butoxycarbonylation of amines with Boc2O in the presence Amberlite-IR 120 under solvent-free conditions. This method is general for the preparation of N-Boc derivatives of both aliphatic (cyclic and acyclic) and aromatic amines.


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