Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Some Studies of E. coli 0H157 on Ducks and some clinicopathological Changes

Author(s): Mona S. Zaki and Nabila El-Batrawy

Forty ducks 6 weeks old and 700 - 900 g average body weight were used. They kept in a balanced diet to study some performance, and clinicopathological changes under E. coli 0157:H7 infection. Ten ducks kept as control and 30 were infected with E. coli 015,: H7 by dose 0.05m1 (x 107 CFU) inoculated intramuscularly. Body weight were recorded, blood samples were collected at 7, 15, 30 days post infection, serum was separated for determination of AST, ALT, Total protein. Albumin, urea, creatinine, calcium phosphorous, sodium, potassium and cortisol hormone. The biochemical analysis showed increase in AST and ALT and a significant change in protein. Hypoalbuminemia, was observed, increase of serum urea, creatinine, hypocalcaemia, hyperphosphatemia, and decrease in level of potassium, sodium and cortisol hormone in areas. Blood examination revealed pancytopenia. This indicates that E. coli 0157: H7 causes deleterious effect on the Hematopoietic system