Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Speciation of binary complexes of Ca(II), Mg(II) and Zn(II) with Lglutamic acid in DMSO-water Mixtures
Author(s): B. Ananda Kumar, S. Raju, K. Bharath Kumar Naik, B. B. V. Sailaja and G. Nageswara RaoChemical speciation of L-glutamic acid complexes of Ca(II), Mg(II) and Zn(II) in the presence of (0-60% v/v) Dimethylsulfoxide-water mixtures has been studied pH-metrically at 303.0K and at an ionic strength of 0.16 mol L-1. The active forms of ligand are of LH3 +, LH2, LH- and L2-. The models containing different number of species were refined by using the computer program MINIQUAD75. The number of species in the models is chosen based on exhaustive modeling. The predominant species detected are ML2H4 2+, ML2H3 +, ML2H2, ML2H- and ML2 2-. The best fit chemical models were arrived at based on statistical parameters. The appropriateness of the models is ascertained by studying the effect of errors in concentrations of ingredients. The trend in variation of stability constants with change in the composition of medium is explained on the basis of electrostatic and non-electrostatic forces. Chemical speciation was discussed based on the distribution diagrams.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
