Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Spectral, Physico-Chemical and Biocidal Studies of Zinc (Ii) Complex with Omeprazole

Author(s): Suman Malik , Supriya Das, Bharti Jain

Metal complex of Zn (II) has been synthesized with 5-methoxy-2[(4methoxy-3, 5dimethyl-2- pyridinyl) methyl sulfinyl]–1H–benzimidazole , a proton pump inhibitor (PPI). Formation of new complex (C17H19N3O3S)2 Zn has been supported by elemental analysis, conductivity measurements and spectral studies including IR,1H NMR,UV, magnetic susceptibility, XRD and SEM studies . The molar conductance measurements of the complex in DMSO indicate that the complex is nonelectrolytic in nature. Analytical data and stochiometry suggest ligand metal ratio of 2:1 for Zn(II) complex. The spectroscopic results show the involvement of C=N and S=O groups in coordination to the central metal ion. Based on spectral studies, tetrahedral geometry has been proposed for the complex. The ligand and its complex were tested for their antibacterial and antifungal activities against bacteria Pseudomonas, Staphylococcus aureus and fungi Aspergillus Niger and A. flavous. It is observed that the complex is a better bactericidal agent than the parent drug.


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