GET THE APP

Spectrophotometric and Cyclic Voltammetric Study of Interaction of Copper with Rizatriptan Benzoate | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Spectrophotometric and Cyclic Voltammetric Study of Interaction of Copper with Rizatriptan Benzoate

Author(s): Malini S, Adinarayana Reddy P, Kalyan Raj

Rizatriptan benzoate is a popular serotonin 5-HT1 receptor agonist triptan drug indicated for the acute treatment of migraine, a neurological disorder. Copper ion plays a key role in brain metabolism. Several neuro diseases are characterised by copper toxicity. The drug binds to copper acetate as revealed by UV and IR spectra. The triazole ring of the drug binds to copper. The cyclic voltammetric studies revealed that with increasing concentration of metal, the corresponding current increases. With increasing scan rate, the corresponding current increases linearly with the square root of the scan rate. This shows that the binding of the drug to the metal is diffusion controlled. The present study investigates the reaction of ascorbic acid with Copper-Rizatriptan complex at neutral pH. The mechanism of reversible formation of Cu(II)/Cu(I) is described based on absorption spectral data.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry