Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Spectrophotometric and Cyclic Voltammetric Study of Interaction of Copper with Rizatriptan Benzoate

Author(s): Malini S, Adinarayana Reddy P, Kalyan Raj

Rizatriptan benzoate is a popular serotonin 5-HT1 receptor agonist triptan drug indicated for the acute treatment of migraine, a neurological disorder. Copper ion plays a key role in brain metabolism. Several neuro diseases are characterised by copper toxicity. The drug binds to copper acetate as revealed by UV and IR spectra. The triazole ring of the drug binds to copper. The cyclic voltammetric studies revealed that with increasing concentration of metal, the corresponding current increases. With increasing scan rate, the corresponding current increases linearly with the square root of the scan rate. This shows that the binding of the drug to the metal is diffusion controlled. The present study investigates the reaction of ascorbic acid with Copper-Rizatriptan complex at neutral pH. The mechanism of reversible formation of Cu(II)/Cu(I) is described based on absorption spectral data.


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