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Spectrophotometric determination of doripenem in bulk and injection formulations by 1,2-naphthoquinone 4-sulphonic acid sodium salt (NQS) reagent in alkalline medium | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Spectrophotometric determination of doripenem in bulk and injection formulations by 1,2-naphthoquinone 4-sulphonic acid sodium salt (NQS) reagent in alkalline medium

Author(s): K. Raghu Babu and N. Aruna Kumari*

A simple and cost effective spectrophotometric method was described for the determination of Doripenem(DP) in pure form and in pharmaceutical formulations. The method is based on the formation of dark yellow colored chromogen when the drug reacts with 1,2 naphtho quinone 4-sulphonic acid sodium salt (NQS) reagent in alkalline medium. The method involves the addition of excess NQS of known concentration in the presence of 0.5 mL NaOH for DP (Method A), the unreacted NQS is determined by the measurement of the λmax 449 nm, which was found to be the most suitable of several tests. This method was applied for the determination of drug contents in pharmaceutical formulations and enabled the determination of the drug in microgram quantities 0.5 to 3.0 mL for DP. No interference is observed from excipients and the validity of the method was tested against reference method. The colored species has an absorption maximum at 449 nm for DP (Method A) and obeys beer’s law in the concentration range 0.02 – 0.12 mg/mL of the drugs The apparent molar absorptivity is 0.0047, sandell’s sensitivitt is 8x10-4. The slope is 0.0997 ± 0.0017 and intercept of the equation of the regression line is -0.0003 ± 0.0033. The optimum experimental parameters for the reaction have been studied and the validity of the described procedure was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The proposed method was successfully applied for the determination of Doripenem in pharmaceutical formulations


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