Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Spectrophotometric Determination of Pregabalin Using Gibb’s and MBTH reagent in Pharmaceutical Dosage Form

Author(s): K. Sowjanya, J.C. Thejaswini*, B.M. Gurupadayya and M. Indupriya

Two simple, extractions free spectrophotometric methods (Method 1 and 2) for the quantitative estimation of Pregabalin (PGB) in bulk drugs and pharmaceutical formulations (capsules) have been developed. Method 1 is based on the formation of a colored oxidative coupling product between 2, 6-dichloroquinone chlorimide and the drug. Colored product at its λmax 400 nm shows linearity in the concentration range of 50-350μg/ml. Second method is based on reaction of oxidative coupling of Pregabalin with 3-methyl-2-benzthiazolinone hydrazone (MBTH) to form green colored product. Colored product of λmax 668 nm shows linearity in the concentration range of 50-350 μg/ml.The relative standard deviations for first method is 0.36% and for second method is 0.35% were obtained. Linear relationships with good correlation coefficients (0.998-0.999) were found between absorbance and the corresponding concentrations of the drug. The reliability and performance of the proposed methods was validated statistically. The percentage recovery ranged from 100.42% and 99.69% respectively.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan