Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Spectrophotometric Determination of Verapamil Hydrochloride using Bromokresol Green

Author(s): Marta Sulyma

Simple, accurate, and precise spectrophotometric method has been developed and validated for the estimation of verapamil hydrochloride in tablets. The method is based on the condensation of verapamil hydrochloride with bromokresol green (BKG) in an acetone medium. The spectrophotometric method based on the measurement of the colored product at 409 nm. The reaction conditions were studied and optimized. Beer’s law was obeyed in the concentration range of 1.9648-4.4208 mg 100 ml-1 with RSD of 8.74 x 10-2 and 3.33 x 10-2 and molar absorptivity of 9.94 x 103, the range of application of the methods is 65-135% of the nominal content of verapamil hydrochloride in the dosage forms.

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