Two simple, economical, precise and accurate methods are described for the simultaneous determination of Dexketoprofen (DKP) and Thiocolchicoside (TCS) in combined tablet dosage form. The first method (Method A) is Absorption Corrected Method and second method (Method B) is First Order Derivative Spectrophotometry.The amplitudes at 300.0 nm and 373.45 nm in the Absorption Corrected Method and 244.14nm and 268.022nm in the first order derivative Spectrophotometry were selected to determine DKP and TCS, respectively in combined formulation. The methods were validated by following the analytical performance parameters suggested by the International Conference on Harmonization (ICH). All validation parameters were within the acceptable range. Under experimental conditions described, calibration curve, assay of tablets and recovery studies were performed. A critical evaluation of proposed methods were performed by statistical analysis of data where slope, intercept, correlation coefficient is shown in Table (1). As per the ICH guidelines, the method validation parameters checked. Beer’s law is Obeyed in the concentration range of 6.25-75 μg/ml for DKP and 1-12 μg/ml for TCS by both the methods.