GET THE APP

Stability indicating simultaneous estimation of assay method for naproxen and esomeprazole in pharmaceutical formulations by RP-HPLC | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

ilbet

süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Abstract

Stability indicating simultaneous estimation of assay method for naproxen and esomeprazole in pharmaceutical formulations by RP-HPLC

Author(s): Palavai Sripal Reddy, Shakil Sait, Gururaj Vasudevmurthy and Badri Vishwanath, Vure Prasad and S. Jayapal Reddy

Naproxen is a Non steroidal simultaneous anti inflammatory drug (NSAID) used in the treatment of pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. Esomeprazole is used to treat gastro esophageal reflux disease. A simple, precise cost effective and stability indicating RP-HPLC method has been developed and validated for the determination of both Naproxen and Esomeprazole in pharmaceutical compositions. Separation of Naproxen and Esomeprazole from its potentional degradants were achieved within a shorter run time with required resolution, accuracy and precision thus enabling the utility of the method for routine analysis. The chromatographic separation was achieved on a Xterra RP-18 column (150 × 4.6 mm, 5μ) using a mobile phase consisting buffer prepared with 0.005 mole of sodium perchlorate, 5 mL N-butyl amine in milli-Q grade water with a pH of 8.7 which is mixed with Acetonitrile and Methanol at a flow rate of 1.5 mL per minute. Wavelength chosen for detection is 305 nm. The retention times of Naproxen and Esomeprazole peaks are around 3 and 6 minute respectively. The method was found to be linear over the range of 100.28 to 902.520 μg per mL for Naproxen and 9.6 to 45.6 μg per mL for Esomeprazole. The proposed method is validated as per the ICH and USP guidelines.


PDF

rokettube brazzers

https://pmasites.com/https://casinositeleriniz.com/https://fbhesq.com/

https://paperio-live.com

wowcappadocia.com
cappadocia-hotels.com
https://babesoflondon.com/
balloon-rides.net

wormax io