In this study, the overlapped spectra of Oxetacaine (OXT), its hydrolytic and oxidative degradation products were well resolved using two simple spectrophotometric methods. The first method depends on measuring the peak amplitudes of first derivative of the ratio spectra (1DD) at 224.3 for selective determination of Oxetacaine in the presence of its degradation products. While in the second method, it was determined by measuring the difference between amplitudes at 216.1 nm and 227.9 nm of the recorded ratio spectra. All the developed methods were validated according to ICH Guidelines, OXT was determined with acceptable accuracy and precision.
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