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Structural identification and characterization of impurities in Esmolol hydrochloride | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Structural identification and characterization of impurities in Esmolol hydrochloride

Author(s): Sahadev Reddy M, M. S. N. Reddya, Rajan S. T, Srinivas Vakaa and Chakravarthy I. E.

In the synthesis of Esmolol hydrochloride four prominent process impurities were formed during synthesis. These impurities were detected in gradient HPLC method. These impurities are synthesized in different synthesis methods and characterized as 3-(4-(2-hydroxy-3-(isopropyl amino) propoxy) phenyl)propanoic acid (Esmolol free acid), Methyl 3-{4- [3-(ethyl amino)-2-hydroxy propoxy]phenyl} propionate (Esmolol isopropyl amide analog), 3-(4-(2-hydroxy- 3(isopropylamino)propoxy)phenyl)-N-isopropylpropanamide (N-Ethyl Esmolol), Methyl 3-(4-(2-hydroxy-3-(3-(4-(2- hydroxy-3-(isopropylamino) propoxy) phenyl)-N-isopropyl propanamido) propoxy)phenyl)propanoate (Esmolol dimer) by 1H NMR, IR and Mass spectral data. Synthesis and Structural elucidation by spectral data is discussed.


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