Structural identification and characterization of impurities in Esmolol hydrochloride | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


Structural identification and characterization of impurities in Esmolol hydrochloride

Author(s): Sahadev Reddy M, M. S. N. Reddya, Rajan S. T, Srinivas Vakaa and Chakravarthy I. E.

In the synthesis of Esmolol hydrochloride four prominent process impurities were formed during synthesis. These impurities were detected in gradient HPLC method. These impurities are synthesized in different synthesis methods and characterized as 3-(4-(2-hydroxy-3-(isopropyl amino) propoxy) phenyl)propanoic acid (Esmolol free acid), Methyl 3-{4- [3-(ethyl amino)-2-hydroxy propoxy]phenyl} propionate (Esmolol isopropyl amide analog), 3-(4-(2-hydroxy- 3(isopropylamino)propoxy)phenyl)-N-isopropylpropanamide (N-Ethyl Esmolol), Methyl 3-(4-(2-hydroxy-3-(3-(4-(2- hydroxy-3-(isopropylamino) propoxy) phenyl)-N-isopropyl propanamido) propoxy)phenyl)propanoate (Esmolol dimer) by 1H NMR, IR and Mass spectral data. Synthesis and Structural elucidation by spectral data is discussed.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry