Studies about newly synthesized quinoxaline fused 1,2,4-triazine derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Studies about newly synthesized quinoxaline fused 1,2,4-triazine derivatives

Author(s): Babu. K, P. Pitchai, M. Sathiyaseelan and A. Nepolraj

Some new pyrazoline derivatives were synthesized by using following synthetic sequences (i) Preparation of (E)-1- (4-aminophenyl)-3-(furan-2yl) prop-2-en-1-one (3a-b) by the reaction between p-NH2-aminoacetophenone (1) and heterocyclic aldehydes(2a-b) (ii) Preparation of (E)-1-(4-((E-)-4-chlorobenzylideneamino) phenyl)-3-(furan-2-yl) prop-2-en-1-one and (E)-1-(4-((E-)-4-chlorobenzylideneamino) phenyl)-3-(thiophene-2-yl) prop-2-en-1-one(5a-b) by the reaction of 3a-bwith p-Cl-benzaldehyde (4). (iii) Preparation of new pyrazoline derivatives 7a-hwas by the cyclysationreaction between 5a-b with semicarbazide, thiosemicarbazide, phenylhydrazine and benzhydrazide(6a-d) in alcohol medium.The structures of the synthesizedcompounds were confirmed by using UV, IR,1H-NMR, and 13CNMR spectral data. The invitro antimicrobial activity of synthesized compounds were evaluated against selective bacteria and fungus and preliminary results showed that most of the compounds showed moderate to good activity


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