GET THE APP

Studies about newly synthesized quinoxaline fused 1,2,4-triazine derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Studies about newly synthesized quinoxaline fused 1,2,4-triazine derivatives

Author(s): Babu. K, P. Pitchai, M. Sathiyaseelan and A. Nepolraj

Some new pyrazoline derivatives were synthesized by using following synthetic sequences (i) Preparation of (E)-1- (4-aminophenyl)-3-(furan-2yl) prop-2-en-1-one (3a-b) by the reaction between p-NH2-aminoacetophenone (1) and heterocyclic aldehydes(2a-b) (ii) Preparation of (E)-1-(4-((E-)-4-chlorobenzylideneamino) phenyl)-3-(furan-2-yl) prop-2-en-1-one and (E)-1-(4-((E-)-4-chlorobenzylideneamino) phenyl)-3-(thiophene-2-yl) prop-2-en-1-one(5a-b) by the reaction of 3a-bwith p-Cl-benzaldehyde (4). (iii) Preparation of new pyrazoline derivatives 7a-hwas by the cyclysationreaction between 5a-b with semicarbazide, thiosemicarbazide, phenylhydrazine and benzhydrazide(6a-d) in alcohol medium.The structures of the synthesizedcompounds were confirmed by using UV, IR,1H-NMR, and 13CNMR spectral data. The invitro antimicrobial activity of synthesized compounds were evaluated against selective bacteria and fungus and preliminary results showed that most of the compounds showed moderate to good activity


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry