Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Studies in the synthesis and applications of 4-(aminomethyl)quinolin-2(1H)-=one derivatives as anti-cancer agents.

Author(s): Radhika Sharma,Shubhangi S. Soman,Shweta V. Patel,Ranjitsinh V. Devkar

2-quinolone derivatives find applications as antimicrobial, anti-viral and anticancer agents. 3-Aryl and N-methyl derivatives of 2-quinolone have been reported as most potent anti-cancer agents. Present study involves synthesis, characterization of novel4-(aminomethyl)quinolin-2(1H)-onederivatives, 7a-e, devoid of 3-aryl and N-methyl substitutions and their application as anti-cancer agents. MTT assay of the synthesized new chemical entities against A549 cell line was carried out and compound 7e was found to be the most potent anti-cancer agent in the series.


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