Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Studies on Chelating Properties of Antipyrine Based Azo Ligands and Its Coordination Compounds

Author(s): Khushbu K Mehta, Sunil T Patel, Asha D Patel

Diazotized p-aminoantipyrine (DpAAP) and salicylic acid upon coupling reaction in the presence of solution of sodium nitrite (aqueous) yields 5-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)diazenyl)-2-hydroxy benzoic acid (DpAAPSA) (L), which upon further reacting with solution of metal acetates (Viz. Cu2+, Ni2+, Co2+, Mn2+ and Zn2+) gave different coordination compounds. The novel azo ligand based on aminoantipyrine was further characterized by elemental analysis, mass, Infrared (IR) and Nuclear Magnetic Resonance (NMR) spectral studies. While the coordination compounds of newly prepared azo ligand were characterized on the basis of metal-ligand stoichiometry (M:L), IR and reflectance spectroscopy and magnetic properties. The antimicrobial activity of DpAAPSA and its coordination compounds was screened against various bacterial and fungal strains. The results show that all these coordinated compounds are good antimicrobial agents.


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