Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Studies on preparation of 2-Acetylbenzimidazole

Author(s): P.Kishore Kumar, P. K. Dubey

o-Phenylenediamine (1) was condensed with lactic acid (2) under Philips conditions to obtain the previously known 2-(α-hydroxyethyl)benzimidazole (3). Oxidation of 3 with K2Cr2O7 in dil. H2SO4 using the literature method gave the previously reported 2-acetylbenzimidazole (4). Several methods have been tried using various oxidising agents / dehydrogenating agents to optimise the preparation of 4 from 3.


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