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Studies on the synthesis and antimicrobial activity of 2-oxo-2H-chromene-3-carbohydrazide derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Studies on the synthesis and antimicrobial activity of 2-oxo-2H-chromene-3-carbohydrazide derivatives

Author(s): Mohamed S. Mostafa, Said H. Kandeel

2-(2-Oxo-2H-chromene-3-carbonyl)hydrazinyl)carbonylbenzoic acids (2a,b) and 4-oxo-4-(2-(2-oxo-2H-chromene- 3-carbonyl)hydrazinyl)butanoic acids (3a,b) were synthesized from the reaction of 2-oxo-2H-chromene-3- carbohydrazides (1a,b) with phthalic anhydride and succinic anhydride, respectively. Sugar hydrazones (4a-f) were prepared by treating compound 1a,b with aldoses. Acetylation of 4a-f with acetic anhydride at room temperature gave the poly-O-acetyl derivatives (5a-f) whereas, treatment of sugar hydrazones 4a-f with boiling acetic anhydride afforded the corresponding 1,3,4-oxadiazoline derivatives (6a-f). The synthesized compounds were screened for their antimicrobial activity.


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