Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Studies on Transition Metal-azo Ligand Chelates

Author(s): Bhavana K Patel

The new azo ligand chelates of Cu(II), Ni(II), Co(II), Mn(II), Zn(II) with 1,3,4-oxidazole and 8-hydroxyquinoline were synthesized and further characterized by FT-IR, elemental analysis and Metal: Ligand ratio as well as reflectance spectra and magnetic moment measurement. Earlier the synthesized ligand was characterized by using Mass, IR and NMR spectroscopy. Analysis of Metal: Ligand ratio suggest all complexes are found in 1:2 (M:L) ratio. The work also includes antifungal activity of the azo-ligand metal chelates was studied against four types of fungal strains which suggest the advantage of coordination to such type of heterocyclic azo-ligand.