Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Study of molecular interactions in antihistamine drug cinnarizine and benzene at different temperatures

Author(s): G. H. Malimath* and C. V. Maridevarmath

In the present work, the ultrasonic studies have been conducted on the binary mixtures of Cinnarizine and Benzene at 2.9979 MHz and at different temperatures from 299K to 328 K using Ultrasonic interferometer. Further, the experimentally determined ultrasonic velocity and density are used to calculate the various thermo-acoustical parameters like adiabatic compressibility (β), intermolecular free length(Lf), specific acoustic impedance(Z), molar volume(Vm), available volume Va(S), Rao’s number(Ra) and Wada’s number(W). The intermolecular interactions responsible for the changes in thermo-acoustical parameters with respect to temperature are discussed. It is noticed that weak molecular interactions are present between the components of the mixture and the molecular interactions are observed to be decreasing with increase in temperature.


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