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Study of some mixed-ligand ternary complexes of Ni (II) ion with drug dapsone as primary ligand and different amino acids as secondary ligand | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Study of some mixed-ligand ternary complexes of Ni (II) ion with drug dapsone as primary ligand and different amino acids as secondary ligand

Author(s): Damini Vishwakarma*, Shraddha Shukla, Anupama Kashyap and Anil Kumar Kashyap

Mixed -ligand ternary complexes of Ni (II) ion with drug dapsone and different amino acids are synthesized and characterized. In this process drug dapsone is used as primary ligand and different amino acids such as prolein, glycine, alanine, histidin, arginine, threonine, valein, methionine, tryptophan and lysine are used as secondary ligand. The prepared ternary complexes were characterized by elemental analysis, UV-Visible and IR spectral analysis as well as magnetic measurements. The general formula [Ni(dap)L]. xH2O were found for the ternary complexes, where L is amino acid and x is the number of coordinated water molecules. From the analytical and spectral data, the stoichiometry has been found to be 1:1:1 for the complexes.


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