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Study of synthesis of novel N,2-diphenylquinazolin-4-amine derivatives as an anti-inflammatory and analgesic agent | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Study of synthesis of novel N,2-diphenylquinazolin-4-amine derivatives as an anti-inflammatory and analgesic agent

Author(s): Bhushan R. Dravyakar, Pramod B. Khedekar

A series of substituted N,2-diphenylquinazolin-4-amines were synthesized by cyclization of methyl anthranilate and various substituted benzamide giving corresponding 2-phenylquinazolinone followed by replacement of ketonic oxygen with various aryl amino group via chlorination gateway to afford title compounds. The homogeneity and purity of compound was ascertained by Physical constant determination and chromatographic methods. The structure of the synthesized derivative was further confirmed by spectral (FTIR, NMR, MS) and elemental (C, H, N) analysis. These synthesized compounds were screened for anti-inflammatory and analgesic activities using, Rat paw edema method and Hot plate method respectively. All compounds showed average to better activity when compared with Diclofenac and Tramadol respectively as standard


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