This study is focused on the application of Azolla Filiculoides (AF) as adsorbents for the removal of the cephalexin (CFX) antibiotic from aqueous solution. Several adsorption parameters including the adsorbent dosage, the initial CFX concentration, contact time and temperature were studied. The kinetic data revealed that the equilibrium time for CFX adsorption was achieved within 75 min. Several kinetic models, i.e., pseudo-first order, pseudo-second order, Weber Morris intraparticle diffusion, were applied, finding that the pseudo-second order model was the most suitable for the fitting of the experimental kinetic data. Thermodynamic parameters such as Gibb's free energy change (ΔG0), enthalpy change (ΔH0) and entropy change (ΔS0) were calculated. The negative values of ΔH0 and ΔG0 indicates that the CFX adsorption process is endothermic and spontaneous in nature. The study showed that AF can be used as a more efficient adsorbent for the adsorption of CFX From water solution.