Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Study of the interaction of the enzyme "mineralocorticoid receptor (MR)" and derivatives spironolactone by molecular docking in solvated medium

Author(s): MostefaouiLarbi , Meriem Merad, Kamal Benmiloud and Said Ghalem

Hypertension is a serious complication that can cause infarctions, stroke [ACV] ... our work is based on the study of spironolactone and its derivatives interaction with the enzyme minéralocorticoïde (MR) by molecular modeling precisely docking using two different software. Our various calculations are performed in medium solvated and non solvated.


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