Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Study of the reactivity of 4-hydroxycoumarin towards 3-oxopyrazolidinium ylures and arylidenemalononitriles
Author(s): Yassine H*, Fatima A, Abderrahim E Haib, Rahhal E Ajlaoui, Said A and El M RakibIn the context of finding new heterocyclic systems pharmacological / biological activities, we were interested in this work in the study of the reactivity of hydroxycoumarin with respect to heterocyclic dipoles of the type: arylmethylidene-3-oxopyrazolidin-1-ium-2-ides 2a–e in acetonitrile in the presence of AlCl3 as catalyst and with arylidenemalononitriles 5a–d in refluxing pyridine. The biscoumarin 3a–e and pyranocomarin 6a–d were obtained with good to excellent yields (74–95%) and characterized by elemental analysis (Scheme 1).
Scheme 1
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