Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Sulfated zirconia: A novel and reusable catalyst for the one-pot synthesis of ├?┬▒-aminophosphonates

Author(s): Y. Prashanthi, N. Bhasker, A. Kavita, R. Srinivas and B. V. Subba Reddy

A new catalytic method has been developed for the one-pot synthesis of α-aminophosphonates via three component coupling of aldehyde, amine and diethyl phophite at room temperature in acetonitrile using sulfated zirconia as a solid super acid catalyst. The recovered catalyst could be recycled for five times with gradual decrease in activity.


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