A novel series of conformationally rigidized N1-substituted-3-aminoalkoxy indoles (tetracyclic derivatives) were designed and synthesized using intramolecular Heck cyclization in presence of tetrakis triphenyl phosphine palladium (0) catalyst. The compounds were characterized with spectral data and were tested for human 5-HT6 receptor binding affinities. All the compounds showed moderate binding affinities towards human 5-HT6 receptor.
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