GET THE APP

Synthesis and antibacterial activities of some N-(p-substituted benzylidene)-5-pentyl-1,3,4-thiadiazole-2-amines | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and antibacterial activities of some N-(p-substituted benzylidene)-5-pentyl-1,3,4-thiadiazole-2-amines

Author(s): Sunil Kumar*, S. K. Sharma, Sandeep Jain, Ashwani kumar and Neelam Jain

A series of Schiff’s bases i.e., N-(p-substituted benzylidene)-5-pentyl-1, 3, 4-thiadiazole-2-amines were synthesized from 2-amino-5-pentyl-1, 3, 4-thiadiazole 1 and evaluated for their in vitro antibacterial activity. Reaction of thiosemicarbazide with pentanoic acid in presence of concentrated sulfuric acid furnished the compound 1 which on further reaction with different p-substituted benzaldehydes yielded the Schiff’s bases 2. These compounds were characterized by spectral analysis. All the synthesized compounds were screened for their in vitro for their antibacterial activity against two Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus) and two Gram negative bacterial strains (Escherichia coli and Pseudomonas aeruginosa) and their minimum inhibitory concentration (MIC) were determined.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry