Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and antibacterial activity of 2-2-[(4-chlorophenyl) sulfanyl] ethoxy-3-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-2-furyl]benzonitrile

Author(s): P. Veerabhadra Swamy, K. B. Chandrasekhar and Pullaiah China Kambhampati

The present paper describes the synthesis and of (2-(4-chlorophenylthio)ethoxy)-3-methoxy-5-(5-(3,4,5- trimethoxyphenyl)furan-2-yl)benzonitrile from commercially available vanillin and 3,4,5-trimethoxy acetophenone as starting materials utilizing green reagents and solvents. The antibacterial test results indicated that the title compound displayed excellent activity against both Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) and Gram-negative bacteria: (Escherichia Coli and Pseudomonas aeruginosa).


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