Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and antibacterial activity of new complexes of benzothiazole derivatives

Author(s): Nitin. H. Bansod, Gajanan. N. Chaudhari, Mangesh S. Thihale and Sahadeo. D. Patil

In present study, five new metal complexes of the ligand 2- amino acetate, 6-chloro benzothiazole with some metal ions Ni(II), Cu(II), Zn(II), Cd(II) and Sn(II) were synthesized and evaluated for their anti-bacterial activity. The prepared complexes were characterized by elemental analysis, magnetic moment, electronic spectra, infrared spectra, conductivity measurement. From spectral measurement, monomer structures for the complexes were proposed. Square planar geometry was proposed for copper complex. The other complexes were proposed to be tetrahedral. The anti-bacterial activities against Gram-positive and Gram-negative pathogenic bacteria were investigated using disc diffusion method. and appreciate activity were observed.


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