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Synthesis and antibacterial activity study of some new 1,3,4-thiadiazole derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and antibacterial activity study of some new 1,3,4-thiadiazole derivatives

Author(s): Rumpa Banerjee, D. Roy and Mrityunjay Banerjee

Six substituted N-aryl,5-substituted phenyl 1,3,4-thiadiazole(7a-f) were synthesized by the reaction of different substituted benzaldehyde with different substituted 5-phenyl 1,3,4-thiadiazole 2-amino in the presence of sulphuric acid in refluxing methanol. The newly synthesized compounds were characterized by spectroscopic methods. Further, the synthesized compounds were screened for antibacterial and antifungal activity by standard method. Results of the activities reveal that some compounds exhibited moderate to good antimicrobial activity.


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