Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis and antibacterial evaluation of some novel aminothiazole derivatives

Author(s): MT Shreenivas, BE Kumara Swamy, GR Srinivasa and BS Sherigara

A series of 4’-(2-n-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl-methyl-biphenyl-2- caboxylic acid- (4-phenyl/ substituted phenyl thiazole)-amide (VI a-g) were prepared. The structures of aminothiazole derivatives were confirmed on the basis of spectral data. The newly synthesized title compounds were screened for their in vitro antibacterial activity. Some of the compounds exhibited encouraging results.